pentobarbital will lessen the extent or result of iloperidone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital boosts toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. CYP3A4 inducers may possibly boost the metabolism of ifosfamide to its Lively alkylating metabolites.
pentobarbital will decrease the level or impact of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
pentobarbital will lessen the level or effect of cobimetinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Prevent coadministration. Powerful or moderate CYP3A inducers may perhaps lower cobimetinib systemic exposure by >eighty% and lower its efficacy.
Contraindicated. CYP3A4 is responsible for the development and elimination of cariprazine's active metabolites. The influence of CYP3A4 inducers on cariprazine exposure has not been evaluated as well as the Web outcome is unclear.
Contraindicated (one)pentobarbital will lessen the extent or effect of dienogest/estradiol valerate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Gals shouldn't pick estradiol valerate/dienogest as their contraceptive even though employing robust CYP3A4 inducers on account of possible reduce in contraceptive efficacy.
Watch Intently (one)pentobarbital will lessen the extent or result of tofacitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Loss of, or reduced response to tofacitinib may occur when coadministered with potent CYP3A4 inducers
Keep an eye on Closely (2)pentobarbital will decrease the extent or outcome of suvorexant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Robust CYP3A4 inducers may possibly lower suvorexant efficacy; if improved suvorexant dose necessary, usually do not exceed 20 mg/working day
pentobarbital will lower the extent or impact of pazopanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
pentobarbital will lower the level or outcome of zonisamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unfamiliar.
pentobarbital will decrease the extent or result of paclitaxel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unidentified.
pentobarbital will decrease the level or result of bosentan by influencing hepatic enzyme CYP2C9/10 metabolism. Small/Importance Unfamiliar.
This drug may well improve the metabolism of estradiol when administered concurrently; patients on oral contraceptives have become Expecting when concurrently addressed with antiepileptic medicine; suggest an alternate contraceptive method to Women of all ages having this drug
pentobarbital will lessen the Nembutal level or effect of glecaprevir/pibrentasvir by impacting hepatic/intestinal enzyme CYP3A4 metabolism.